There are sandwiches, and then there are sandwiches that stop you in your tracks. This cold Muffuletta Sandwich with Homemade Focaccia Bread is just that. It’s loaded with layers of Italian deli meats, sharp provolone, and a punchy olive pickle mix, all tucked into pillowy, golden-baked focaccia.

The best part? You can make it ahead and let the flavors get cozy in the fridge. It’s perfect for picnics, road trips, or casual lunches where you want something impressive but low-effort. It’s so good on its own, but it will pair nicely with one of my Mediterranean Salad Recipes.

Muffuletta sandwich made with fresh homemade focaccia stuffed with cheese and deli meat on a plate with a side of hot peppers.

Why This Recipe Works

  • Easy but impressive. The homemade focaccia requires no kneading or stand mixers, and the sandwich comes together in minutes once you have your ingredients prepped. The bread recipe is based on my Same Day Focaccia recipe. It’s soft yet sturdy, making it a perfect vehicle for the meat and cheese.
  • Perfect for warm weather. Served cold, muffuletta sandwiches are refreshing, hearty, and ideal for summer gatherings.
  • Pairs beautifully. Try it with a crisp green salad, sparkling water, or even a chilled glass of white wine.

Ingredients

As simple as it gets. You only need 5 ingredients for the base focaccia recipe. Here’s what you’ll need:

Muffuletta sandwich bread ingredients on a board with individual labels.
  • Flour. I am using all-purpose flour. It’s easy, it’s readily available, and everyone has it. Bread flour gives a chewier texture, but both work great. If you want to use some whole wheat flour in this recipe, sub out a quarter to a half of the white flour for whole wheat, just like how I do it in my Whole Wheat No Knead Focaccia recipe.
  • Yeast: I like to use Instant yeast in most of my Baking Recipes, but active dry yeast will work just fine too. Just make sure to bloom it in the water for a few minutes before adding the flour. You can also use fresh yeast but do adjust the quantity. When using fresh yeast instead of dry, use double the amount by weight.
  • Olive oil. You are going to need quite a bit of good olive oil for this recipe. Use good quality extra virgin olive oil for that rich, classic focaccia flavor.
  • Toppings: In this recipe, I am keeping it simple with fresh rosemary and flaky salt. Sesame seeds are traditional in muffuletta bread.

When it comes to the sandwich itself, here’s what you will need:

Muffuletta sandwich recipe ingredients with individual labels on a metal tray.
  • Mixed deli meats: A combo of Italian cold cuts (genoa salami, spicy salami, mortadella, and coppa or capicola ham) gives the best flavor, but feel free to use what you have on hand or whatever you prefer. Make sure to also try my Antipasto Bean Salad for a similar flavor profile!
  • Cheese. Mild provolone works beautifully here. You can substitute with sliced mozzarella, Swiss cheese or fontina if needed. I’ve also made it in the past with smoked gouda, though not really traditional.
  • Muffuletta Mix. A zesty blend of olives, pickled vegetables, and spices. Usually sold at your local Italian market or grocery store. You can find it in Italian delis too. Can’t find it? Substitute with a mix of olive tapenade, olive spread, zesty olive salad mix or pickled eggplant for a similar tangy bite.

Refer to the recipe card at the bottom of this post for a full list of ingredients and quantities.

How to Make this Muffuletta Recipe

The steps are quite straightforward, but I recommend that you read through everything to get comfortable with the process.

Recipe steps showing how the dough is mixed in a large bowl.

Step 1. Mix the Focaccia Dough. In a large bowl, combine the flour, instant yeast, kosher salt, lukewarm water, and olive oil (Image 1). Mix using a fork, wooden spoon or Danish whisk until well combined and a shaggy dough forms (Image 2). The flour should be fully hydrated. Cover with a tea towel or plastic wrap and set aside for 30 minutes (Image 3).

Recipe steps showing how the dough is stretched from one side, then folded over. The bowl is then turned 90 degrees and the stretching and folding step is repeated.

Step 2. Stretch and Fold. Wet your hands and perform a stretch and fold. Grab the dough from one side, gently pull up and fold it over (Images 4-5). Rotate the bowl 90 degrees and repeat 3 more times (Images 6-7). Cover and let rest for 30 minutes. As you do this, try to scrape down any dough stuck to the sides of the bowl.
Step 3. Repeat Stretch and Fold. Repeat the stretch and fold process every 30 minutes, for a total of 3 rounds over 1.5 hours. At this point, the dough should be much smoother.

Recipe step showing the dough being placed in an oiled round baking pan.

Step 4. Transfer. Grease an 8 or 9-inch round baking tray with butter and olive oil. Transfer the dough to the prepared pan, fold it gently like a letter, then flip it so the seam is on the bottom. Cover and rest for 1 hour (Images 8-9).

Recipe steps showing the dough in the round baking pan, getting dimpled, dressed and baked.

Step 5. Stretch. Preheat the oven to 450°F/230°C. If the dough hasn’t spread fully, lightly oil your hands and stretch it gently into the corners of the baking pan (Image 10).
Step 6. Dimple and Dress. Drizzle olive oil on top of the dough and dimple with your fingers (Image 11). Sprinkle with rosemary and flaky sea salt (Image 12).
Step 7. Bake. Bake for 18-22 minutes until golden brown. Let cool completely (Image 13).

Recipe steps showing how the round focaccia bread is sliced, then layered with cheese and deli meats, then topped with the muffuletta mix and sliced.

Step 8. Slice. Slice the bread in half. Try to make sure both the top and bottom pieces are the same thickness (Image 14).
Step 9. Layer. Layer on the mixed deli meat slices and provolone cheese (Image 15).
Step 10. Add Pickle Mix. Spoon over the muffuletta mix or tapenade (Image 16).
Step 11. Slice. Place the top back on the large sandwich and slice it into 4 or 6 wedges, depending on your preference. Serve cold or at room temperature with a side of potato chips, French fries, potato salad and/or pepperoncini peppers (Image 17).

Cross-section of a muffuletta slice showing the deli meat and cheese.

Expert Tips

  • Use a kitchen scale. I have provided US customary measurements, but for accuracy, I recommend that you weigh out your dough ingredients.
  • How old is your yeast? If your yeast container has been opened for over a year, consider buying new yeast before making this recipe.
  • Don’t skip the stretch and folds! They help build structure without kneading. It’s the same process I outlined in my Tuscan Flatbread (Schiacciata) recipe.
  • Use a metal baking pan. Metal pans are easier to work with and less likely to cause your focaccia to stick. I like to use an 8-inch round pan, but a quarter baking sheet pan will work too. Glass is notorious for sticking, so avoid it if you can. Or use parchment paper.
  • BUTTER THE PAN! Before you oil the pan, butter it. The butter creates a layer between the pan and the dough, making it so incredibly easy to remove the bread from the pan once baked.
  • Let it cool fully before cutting using a serrated knife. This keeps the crumb nice and airy. If you cut it too soon, the focaccia may turn gummy.
  • Letting the sandwich rest overnight enhances the flavors.
  • The sandwich travels well, making it ideal for picnics or road trips.
  • Other additions: You can add other sandwich toppings if you like, such as sliced black olives, green olives, roasted red peppers, fresh mozzarella, a layer of lettuce, chopped artichoke hearts or tomato relish.
Muffuletta sandwich made with fresh homemade focaccia stuffed with cheese and deli meat, wrapped in paper and sitting on a wooden tray.

Recipe FAQs

Can I make Muffuletta ahead of time?

Yes! It actually tastes better the next day. Assemble it up to 24 hours in advance and refrigerate. A great way to meal prep or plan ahead for a gathering.

How do I store leftover Muffuletta?

Wrap tightly and store in the fridge for up to 3 days.

Where does the muffuletta come from?

The muffuletta sandwich has roots in Sicily but became iconic in New Orleans. It was created by Italian immigrants in the early 1900s, particularly at Central Grocery Co. on Decatur Street. The name comes from the traditional round Sicilian sesame topped bread called “muffuletta.” Over time, the sandwich evolved into a hearty cold cut and olive salad combo, representing a delicious blend of Old World tradition and American innovation.

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Muffuletta Recipe with Homemade Focaccia Bread

There are sandwiches, and then there are sandwiches that stop you in your tracks. This cold Muffuletta Sandwich with Homemade Focaccia Bread is just that. It’s loaded with layers of Italian deli meats, sharp provolone, and a punchy olive pickle mix, all tucked into pillowy, golden-baked focaccia.
Servings: 6 Portions
Cross-section of a muffuletta slice showing the deli meat and cheese.
Prep Time: 20 minutes
Cook Time: 20 minutes
Rise Time: 3 hours
Total Time: 3 hours 40 minutes
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Equipment

Ingredients 

For the Base Dough (weigh it out if possible)

  • 250 grams All purpose flour cups
  • 5 grams Kosher salt 1 tsp
  • 4 grams Instant yeast 1 tsp
  • 14 grams Extra virgin olive oil 1 tbsp
  • 200 grams Lukewarm water 0.85 cups

For Greasing the Pan

  • ½ teaspoon Butter
  • 1-2 tablespoon Extra virgin olive oil

Topping the Bread

  • 1-2 tablespoon Extra virgin olive oil
  • ½-1 teaspoon Fresh rosemary – Optional
  • 1 teaspoon Flaky salt – Just a light sprinkle

Sandwich Ingredients

  • 1 lb Mixed deli meat (mortadella, capicola, salami) – about 450 grams
  • 5 oz Provolone cheese – about 140 grams
  • ½ cup Muffuletta pickle mix – about 75 grams, use more if you like

Instructions 

Bake the Bread

  • Mix the Focaccia Dough. In a large bowl, combine 250 grams All purpose flour, 5 grams Kosher salt, 4 grams Instant yeast, 14 grams Extra virgin olive oil and 200 grams Lukewarm water. Mix using a fork, wooden spoon or Danish whisk until well combined and a shaggy dough forms. The flour should be fully hydrated. Cover with a tea towel or plastic wrap and set aside for 30 minutes.
  • Stretch and Fold. Wet your hands and perform a stretch and fold. Grab the dough from one side, gently pull up and fold it over. Rotate the bowl 90 degrees and repeat. Repeat 2 more times. As you do this, try to scrape down any dough stuck to the sides of the bowl. The dough might break on this first set. Don't worry, the gluten will keep developing and the dough will become stretchy over time. Cover and let rest for 30 minutes.
  • Repeat Stretch and Fold. Repeat the stretch and fold process every 30 minutes, for a total of 2 to 3 rounds over 1.5 hours. At this point, the dough should be much smoother.
  • Transfer. Grease a baking tray with ½ teaspoon Butter and 1-2 tablespoon Extra virgin olive oil. Transfer the dough to the prepared pan, fold it gently like a letter, then flip it so the seam is on the bottom. Cover and rest for 1 hour.
  • Preheat the oven to 450°F/230°C.
  • Stretch. If the dough hasn’t spread fully, lightly oil your hands and stretch it gently into the corners of the baking pan.
  • Dimple and Dress. Drizzle 1-2 tablespoon Extra virgin olive oil on top of the dough and dimple with your fingers. Sprinkle with ½-1 teaspoon Fresh rosemary and 1 teaspoon Flaky salt.
  • Bake. Bake for 18-22 minutes until golden brown. Cool completely.

Make the Sandwich

  • Slice. Slice the bread in half. Try to make sure both the top and bottom pieces are the same thickness.
  • Layer. Layer on 1 lb Mixed deli meat (mortadella, capicola, salami) and 5 oz Provolone cheese.
  • Add Pickle. Spoon over ½ cup Muffuletta pickle mix creating an even layer.
  • Slice. Place the top onto the sandwich and cut into 4 or 4 wedges.

Notes

Refer to the blog post above for step-by-step recipe photos, tips and helpful advice. 
Use a kitchen scale. I have provided US customary measurements, but for accuracy, I recommend that you weigh out your dough ingredients.
Key Ingredient Notes:
  • Flour: I am using all-purpose flour. It’s easy, it’s readily available, and everyone has it. Bread flour gives a chewier texture, but both work great. If you want to use some whole wheat flour in this recipe, sub out a quarter to a half of the white flour for whole wheat.
  • Yeast: I like to use Instant yeast in most of my Baking Recipes, but active dry yeast will work just fine too. Just make sure to bloom it in the water for a few minutes before adding the flour. 
  • Muffuletta Toppings: Traditionally, you would use a combination of provolone cheese and mixed deli meats like mild salami, spicy salami, mortadella, capicola and/or prosciutto. You can create your own mix, just use what you like. 
  • Muffuletta pickle: You may not find this pickle mix everywhere, but if available, use it. It has a fine mixture of pickled vegetables, olives and spices. You can also use mild or spicy pickled eggplant strips. Olive tapenade is a good substitution too. 

Nutrition

Calories: 544kcal, Carbohydrates: 35g, Protein: 24g, Fat: 34g, Saturated Fat: 13g, Polyunsaturated Fat: 3g, Monounsaturated Fat: 16g, Trans Fat: 0.03g, Cholesterol: 60mg, Sodium: 1513mg, Potassium: 220mg, Fiber: 2g, Sugar: 0.2g, Vitamin A: 229IU, Vitamin C: 0.01mg, Calcium: 201mg, Iron: 3mg

Nutrition information is automatically calculated, so should only be used as an approximation.

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2 Comments

  1. Vita says:

    Best tasting quick focaccia. I ate half the loaf before I even made it to sandwich making phase. Thanks.

    1. Luay Ghafari says:

      Glad you enjoyed, Vita!